Role of Early-life Gut Microbiome in the Developmental Origins of Health and Disease (DOHaD)
Hein Min. Tun (Research Assistant Professor, School of Public Health, University of Hong Kong, HKSAR)
The prominent role of the microbiome in human health has been established over the past decade, and the early-life microbiome is now being as a major influence on long-term human health and development. Several lifestyle factors, such as mode of birth, breastfeeding, diet, and antibiotic usage influence on the composition and functional potential of the early-life microbiome. In addition, perturbations of the early-life microbiome composition have been associated with specific disease outcomes, such as allergies, asthma, obesity, and neurodevelopmental disorders. Role of the microbiome in the Developmental Origins of Health and Disease is supported in this collective research. Highlighting the early-life critical window of susceptibility associated with microbiome development, Dr. Tun will summarize his published and unpublished data demonstrating how early-life events and environmental factors impact on the colonization and development of infant gut microbiota. In addition, he will also discuss the available disease-specific evidence pointing toward the microbiome as a mechanistic mediator in the Developmental Origins of Health and Disease.
Hein Min Tun, Research Assistant Professor, School of Public Health, University of Hong Kong, received his BVSc (Gold Medal) degree from the University of Veterinary Science in 2007 and MSc degree from Chulalongkorn University in 2010. After obtaining PhD degree from the University of Hong Kong in 2014, he then moved to Canada to pursue this postdoctoral research at the Gut Microbiome Laboratory of the University of Manitoba where he held an additional role as a lab manager. 2 years later, he joined in the Department of Pediatrics in the University of Alberta to study roles of infant gut microbiome in health and diseases using the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort.